'Best Medicine' Season 2 Release Schedule: When Do New Episodes Drop?

Small-town drama is officially back on the screen as *Best Medicine* returns for its highly anticipated second season. The medical comedy-drama is expanding its footprint this year, giving fans an extra hour of strange medical dilemmas and small-town antics compared to its inaugural run. Viewers can expect even more chaotic house calls and quirky village conflicts in the fictional coastal community of Port Wenn. The series stars two-time Emmy nominee Josh Charles as Dr. Martin Best, a brilliant big-city surgeon whose career takes an unexpected turn after a disastrous mishap in the operating room. Forced to pivot, he relocates to a remote fishing village to act as the resident general practitioner. Unfortunately, his distant personality, loner habits, and notoriously awful bedside manner immediately put him at odds with the eccentric townspeople.

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While the show initially debuted as a midseason entry in early 2025, network executives bumped the series into a major autumn broadcasting slot for Season 2. The new chapter kicks off with a special early premiere on Sunday, Sept. 20. After that special initial launch, the series will re-air in its regular timeslot as new weekly episodes continue to drop across broadcast television and streaming platforms. In addition to Josh Charles, the returning cast brings plenty of recognizable star power to Port Wenn. Abigail Spencer, famous for her performances in *Suits* and *Timeless*, returns alongside legendary actress Annie Potts of *Designing Women* and *Young Sheldon* fame. Comedy favorite Josh Segarra, a recent standout in *Abbott Elementary* and *Animal Control*, also returns to the ensemble.

BUZZBEAT

Storylines for the second season promise higher stakes and stranger medical cases than ever before. As Dr. Best attempts to navigate his new normal, the charming small-town vibes provide a cozy backdrop to his ongoing personality clashes with the local residents. With extra running time and a refreshed fall schedule, *Best Medicine* is shaping up to be a comforting autumn favorite for TV audiences looking for a blend of quirky humor and heart.